indigo carmine toxicity

Published by on November 13, 2020

There is no data in patients with liver impairement, however no dosage adjustment is necessary. Epub 2011 Nov 18. They are in the files of commercial testing laboratories, government agencies or sponsoring industrial corporations. A low acute oral toxicity was indicated in rodents, whilst anaemia has been seen in mice and pigs subject to repeated oral exposure. The recommended initial dosage is 1 ampoule of 5 mL by slow intravenous injection. It is quickly eliminated from the plasma compartment and it is easily and largely eliminated by the kidney. This medicinal product is to be injected by intravenous route. However, long-term studies in rats (oral) and mice (subcutaneous) have not revealed any carcinogenic effects. Obstet Gynecol. It is an indicator at pH 11.5-14, changing from blue to yellow. In this context, this study aimed to evaluate Indigo Carmine toxicity to soil organisms using the earthworm Eisenia andrei as a model-organism and also verify the efficiency of AOP in reducing its toxicity to these organisms. To this end, lethal (mortality) and sub-lethal (loss or gain of biomass, reproduction, behavior, morphological changes and immune system cells) effects caused by this substance and its degradation products in these annelids were evaluated. No case of overdose has been reported in the literature for doses up to 80 mg of indigotin (indigo carmine) administered intravenously. Slow intravenous injection under monitoring of arterial pressure and heart rate. To bookmark a medicine you must sign up and log in. Precautions to be taken before administering the medicinal product. 2018 Jan;147:1-8. doi: 10.1016/j.ecoenv.2017.08.018. Keywords:  |  In patients with a clearance of creatinine < 10 mL/min, Indigo carmine should not be used (see section 4.4). 2020 Sep;27(27):33474-33485. doi: 10.1007/s11356-019-05440-3. A small amount is excreted in the bile. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. Es wird als pH-Indikator verwendet.Oberhalb von einem pH-Wert von 13 ist es gelb, unterhalb von 11,4 blau. In the chronic study, the organisms displayed a mortality rate of 14%, while those exposed to the photoproduct reached up to 32.7%.  |  Indigotin (indigo carmine) should be used with caution in case of: • concomitant use of medicines inducing bradycardia. Indigotin (indigo carmine) is a dye clinically used for diagnostic purposes. 2015 Aug;187(8):530. doi: 10.1007/s10661-015-4742-9. No carcinogenicity study has been conducted by intravenous route with indigotin (indigo carmine). IC increased LDH expression and reduced vital cell number after a short treatment time of 10 minutes. Date of first authorisation/renewal of the authorisation. Indigo Carmine is excreted largely by the kidneys, retaining its blue color during passage through the body. Continue typing to refine. Indigo carmine was slightly irritating to the eyes of rabbits. Considering the dark blue colour of Indigo carmine, a filtration is recommended during the intravenous administration (for example a filter of 0.45 µm, with a filtering surface of at least 2.8 cm², composed of a hydrophilic polyethersulfone membrane). Copyright (c) 2014 Bibra toxicology advice & consulting Ltd. All rights reserved. The biological half-life is 4 to 5 minutes following intravenous injection. Bioindicator; Dye; Earthworm; Immunotoxicity; Photodegradation. Reproductive and behavioral responses of earthworms exposed to nano-sized titanium dioxide in soil. Acute toxicity data for indigotin (indigo carmine) are available from rat and mouse studies. It contains an indigo carmine(2-). Epub 2019 May 22. Indigo carmine is not recommended during pregnancy and in women of childbearing potential not using contraception. There are no or limited amount of data from the use of indigotin (indigo carmine) in pregnant women. Serious adverse reactions of indigotin (indigo carmine) are very rare. Oral administration to male rats gave no evidence of (dominant lethal) mutations although mutagenicity was observed in mammalian cells in culture. Epub 2015 Jul 28. This medicinal product is for diagnostic use only. Toxicity Profile for Indigo carmine (1995), E-cigarettes and other Nicotine Delivery Devices, Pharmaceutical Product Toxicological Support, Government departments and international agencies, TGA safety assessment of low dose cannabidiol, NTP finalises toxicology and carcinogenicity report on perfluorooctanoic acid (PFOA), COC finalises guidance statement on epigenetics, New WHO Environmental Health Criteria document on the immunotoxicity of nanomaterials, Toxicology and Regulatory News – Contents Archive June 2020. demonstrate carcinogenic or toxic effects. HHS Pharmacotherapeutic class: DIAGNOSTIC AGENTS, ATC Code: V04CH02. As an alternative to wastewater treatment, advanced oxidative processes (AOPs) have been highlighted due to their high capacity to destruct organic molecules. The organisms exposed to the IC during the contact test showed mortality after 72h of exposure (LC50 = 75.79mgcm-2), while those exposed to photoproducts showed mortality after 48h (LC50 = 243min). A discolouration of urine may be observed following administration of indigotin (indigo carmine). Pereira PCG, Soares LOS, Júnior SFS, Saggioro EM, Correia FV. Sub-lethal effects of the pesticide imazalil on the earthworm Eisenia andrei: reproduction, cytotoxicity, and oxidative stress. In case of overdose, a peripheral vasodilator therapy may be considered. Please enable it to take advantage of the complete set of features! Copyright © 2017 Elsevier Inc. All rights reserved. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. Indigo carmine is an organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. Animal studies are insufficient with respect to reproductive toxicity (see section 5.3). Continue, 2. Toxicology of indigo. Reporting suspected adverse reactions after authorisation of the medicinal product is important. NLM Ecotoxicol Environ Saf. Environ Sci Pollut Res Int. 2013 Feb;121(2 Pt 2 Suppl 1):449-51. doi: 10.1097/aog.0b013e31826d21ec. IC is traditionally used as pH indicator or food colorant. Weiterhin wird es als Redox-Indikator verwendet, der sich bei einer Reaktion gelb verfärbt.Er wird auch zum Anzeigen von gelöstem Ozon eingesetzt. NIH In rats, the LD50 (median lethal single dose) is 93 mg/kg by intravenous route while in mice the LD50 is 405 mg/kg by subcutaneous route. The efficacy and safety of Indigo carmine in children has not been established (see section 4.4). Environ Toxicol Chem. Get the latest research from NIH: https://www.nih.gov/coronavirus. This site needs JavaScript to work properly. An overdose could induce a hypertensive crisis and severe bradycardia. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). Indigotin (indigo carmine) may interfere with pulse oxymetric methods. Most reports relating to the biological and toxicological properties of indigo have never been published in scientific journals. Owing to its toxicity, wastes containing this compound should be treated to minimize or eliminate their toxic effects on the biota. The use of indigotin (indigo carmine) should be avoided in patients with: No interaction studies have been performed. Effects of metals on earthworm life cycles: a review. In patients with a clearance of creatinine ≥ 10 mL/min, Indigo carmine may be administered. Respiratory, thoracic and mediastinal disorders.

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