monocrotophos toxicity humans

Published by on November 13, 2020

To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. According to the WHO, swallowing 1,200 milligrams - less than a teaspoon - of monocrotophos can be fatal to humans. Cases have been described of deliberate self-poisoning which has higher mortality than accidental exposure. A 32-year-old man was admitted to a peripheral hospital following assault with a 100-ml bottle of insecticide called Monocrotophos, an organophosphate. Monocrotophos is principally used in agriculture, as a relatively cheap pesticide. Extremely toxic; probable oral lethal dose to humans 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) Organophosphate poisoning is a continued menace associated with high morbidity and mortality in both resource-crunched developing and developed countries. person. In 2009, it called for India to ban the product because of its extreme toxicity. Usually, poisoning is by ingestion for suicidal purposes, although accidental poisoning is not uncommon. Monocrotophos is not irritating to skin and eyes. Fate in Humans and Animals: Monocrotophos is metabolized and excreted rapidly and does not appear to accumulate within the body (171). Monocrotophos is an organophosphate insecticide. Organ Toxicity: Monocrotophos affects the central nervous system by inhibiting cholinesterase, an enzyme essential for normal nerve impulse transmission. Monocrotophos, an organophosphate, was first registered in Australia in 1968 and has played a useful role in agriculture as a broad spectrum, systemic insecticide and acaricide in crops such as sorghum, sunflowers, tomatoes and tobacco. 11 12 Monocrotophos inhibits acetylcholinesterase (ChE) activity resulting in an excess of 13 acetylcholine at neuronal synapses and myoneural junctions. The genotoxic and cytotoxic effects of monocrotophos, an organophosphate insecticide, was investi- gated on human lymphocytes cultured in vitro. It is acutely toxic to birds and humans, so it has been banned in the U.S., the E.U. Monocrotophos can be absorbed into the human body through multiple pathways, including inhalation, skin contact and ingestion, and is acutely toxic by all routes of exposure. Monocrotophos was proposed for review in 1996 as part of the second group of chemicals Investigation of monocrotophos toxic effects on human lymphocytes at cytogenetic level B. Kalyan Chakravarthi 1 , Rambabu Naravaneni 2 , G. H. Philip 1 and C. Srinivasulu Redddy 3 The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. Poisoning due to absorption through intact or damaged skin is rare. Its cholinesterase inhibiting activity causes nervous system effects. Uses. 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