schizophrenia medication side effects akathisia

Published by on November 13, 2020

Curr Neuropharmacol. Movements may be accompanied by vocalization such as grunting and moaning [5]. It is one of the most common side effects of antipsychotic medications; between 15% and 45% of people who take antipsychotic medications experience akathisia. However, it may be hard to describe by patients and thus hard to diagnose by doctors. By day 45, when the patient presented for her next review, her symptoms of akathisia had resolved. (1) Are there previous conclusive reports on this reaction? Will I Gain Weight If I Take Zyprexa for My Bipolar Disorder? Case B’s presentation of moderate akathisia may be associated with fluoxetine-fluphenazine interaction and/or olanzapine-ciprofloxacin interaction. Case B was a 17-year-old African female admitted and managed for first-episode depression with psychotic symptoms. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Block, MD, How the Atypical Antipsychotic Lurasidone Is Prescribed, Common and Serious Side Effects of Trilafon (Perphenazine), Side Effects of Thorazine for Bipolar Disorder. Furthermore, all the 4 medicines mentioned above can cause akathisia on their own. It is commonly associated with, but not limited to, the use of antipsychotics [3–5]. It occurs, in most instances, within four weeks of initiating antipsychotic therapy [6]. The Barnes Akathisia Rating Scale--revisited. Sign up here as a reviewer to help fast-track new submissions. In view of this, the dose of haloperidol tablet was reduced to 2.5 mg daily with plans to stop gradually. It's important to note that all antipsychotic drugs carry with them the risk of causing akathisia. Citrome, Leslie Strategies to consider in the management of akathisia are dose reduction or substitution with a drug with lesser propensity to cause akathisia [9]. The patient was also hypertensive and managed uneventfully on amlodipine 10 mg tablet daily, bendroflumethiazide 2.5 mg tablet daily, and atenolol 50 mg tablet daily. In one case report, ciprofloxacin was linked to a probable cause of akathisia in a woman who had taken ciprofloxacin one month earlier for sinusitis prior to presentation of severe akathisia [12]. At her next review which was on day 42, there were no complaints; neither symptoms of akathisia nor depression with psychosis was present. These complaints were distressing enough to account for her medication nonadherence. Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. The patient presented for review on day 21 with complaints of worsening obsessive thoughts. (4) Did the adverse event reappear when the drug was readministered? Despite these management measures, the symptoms of akathisia persisted and only resolved after 4weeks. However, when these complaints persist over a period of 2 weeks to 1 month and/or have the appearance of a relapse, especially in patients on maintenance therapy, an underlying cause ought to be established. One of the adverse effects is akathisia. The Barnes Akathisia Rating Scale--revisited, The incidence of akathisia in the treatment of schizophrenia with aripiprazole, asenapine and lurasidone: A meta-analysis, The assessment and treatment of antipsychotic-induced akathisia, Selective serotonin reuptake inhibitors (SSRIs). Her medications on admission were fluphenazine decanoate 25 mg depot injection, diazepam 10 mg injection once (and thereafter when needed but not to exceed 30 mg in a day), olanzapine 10 mg tablet daily, and benzhexol 5 mg tablet daily when necessary. In 1998, Lane presented a report on the propensity of selective serotonin reuptake inhibitors (SSRIs) to induce akathisia when combined with antipsychotics. (3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered? 2015;14(1):14-18. while the first-generation, older meds usually cost less, they can have different side effects than the newer antipsychotics. One such underlying cause could be an adverse drug-drug interaction between antipsychotics, antidepressants, and antimicrobials. Revisiting antipsychotic-induced akathisia: Current issues and prospective challenges. Avoidance of this combination (risperidone+fluoxetine) is recommended. Case B’s presenting complaints were restlessness, tremor, abdominal discomfort, constipation, and weight gain. Her medications on admission were fluphenazine decanoate 25 mg depot injection once, olanzapine 10 mg tablet daily, and fluoxetine 20 mg capsule daily. In addition, your doctor will ask about your current medications and rule out any other health conditions that can cause similar symptoms, including: While akathisia is a common side effect of certain medications, researchers have yet to understand why or how it causes symptoms of restlessness. If you suspect akathisia, it’s important to see your doctor to get an official diagnosis. 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