perfluorooctanoic acid health effects

Published by on November 13, 2020

It has been observed that PFOA alters the calcium homeostasis and decreased the viability of colon carcinoma (HCT116) cells over time [, Despite these studies, there is still limited evidence on the toxicity of PFOA on intestinal epigenetics and tight junction (TJ) genes. 2010 (n = 55,000)]. Tursiops truncatus However, whether this shared transporter hypothesis is relevant in humans remains speculative at this point. The mortality of workers (n = 6,207) at a DuPont plant using PFOA, who were employed between 1948 and 2002, has been studied by Leonard et al. 2009a). Barry, V.; Winquist, A.; Steenland, K. Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant. Results are presented in terms of regression coefficients for log-transformed variables, which are sometimes hard to interpret in terms of strength of effect. 2010; Steenland et al. Yara, S.; Lavoie, J.-C.; Beaulieu, J.-F.; Delvin, E.; Amre, D.; Marcil, V.; Seidman, E.; Levy, E. Iron-Ascorbate-Mediated Lipid Peroxidation Causes Epigenetic Changes in the Antioxidant Defense in Intestinal Epithelial Cells: Impact on Inflammation. These results provide limited evidence of some biological activity of PFOA in human liver, the clinical significance of which is uncertain. Address correspondence to K. Steenland, Rollins School of Public Health, Emory University, 1518 Clifton Rd., Atlanta, GA 30322 USA. Extrapolation across species and end points is particularly problematic in reproductive toxicology. Although the occupational studies have the advantage of substantially elevated exposure ranges, they suffer from several limitations. However, there are very limited human data on hormones in relation to serum PFOA, found in three occupational cross-sectional studies. The data from both occupational cohorts are clearly quite sparse and prohibit any firm conclusions. 2007; Loveless et al. 2007). ; Tian, Y.; Smith, P.B. (2008a) examined parent-reported developmental milestones in infants 6 and 18 months of age and found no indication of delays associated with higher PFOA exposure. Animal studies have demonstrated that PFOA causes lymphoid organ atrophy and decreased de novo antibody production in certain strains of mice (DeWitt et al. (2010), both PFOA and PFOS were significantly associated with uric acid. Serum PFOA levels among all workers at this plant in 2004 averaged 240 ng/mL, with an average of 490 ng/mL among workers in the PFOA areas (Sakr et al. Fax: (404) 727-8744. However, some figures and Supplemental 2003; Sakr et al. 2007). contact 2009). PFOA and PFOS are generally correlated in the serum; in two large studies, the correlations were 0.31 (in a population with high-PFOA exposure; Steenland et al. Drinking water is the primary route of exposure in some populations, but exposure sources are not well understood. Telephone: (404) 712-8277. Sochorová, L.; Hanzlíková, L.; Černá, M.; Drgáčová, A.; Fialová, A.; Švarcová, A.; Gramblička, T.; Pulkrabová, J. Perfluorinated alkylated substances and brominated flame retardants in serum of the Czech adult population. 2009; Olsen et al. Cases were restricted to those validated by medical records and occurring in the 10 years before 2005 (n = 1,055). 2009). (2008a) examined parent-reported developmental milestones in infants 6 and 18 months of age and found no indication of delays associated with higher PFOA exposure. In contrast to these important but inherently limited sources of epidemiologic information, we are pursuing an unusual opportunity to extend our knowledge regarding the health effects of PFOA considerably by conducting a series of studies of an exposed community population in the Mid-Ohio Valley (Frisbee et al. 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